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Science Seminar Series: Redox Biology: from Physiological Adaptation to Mechanisms of Disease

Tuesday, November 7, 2017 12 pm to 1 pm

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Professor Jose P. Vazquez-Medina from the Department of Integrative Biology at UC Berkeley, will be our guest speaker for this month's Science Seminar Series.

Reactive oxygen species (ROS) play a key role in cellular signaling during health and disease. Although most of the research in this area has focused on dysregulated oxidant generation in human disease, Vazquez-Medina has been studying the role of redox signaling in physiological responses of animals adapted to extreme conditions.

Elephant seals are a prime example of extreme physiological adaptation as they can hold their breath for extended periods while diving and sleeping. Remarkably, extended breath-holding in seals is associated with severe hypoxemia and ischemia but does not result in the cardiovascular complications observed in humans that suffer from heart attacks, pulmonary embolism or sleep apnea.

Vazques-Medina's research group are currently using cell culture systems to dissect cellular mechanisms that drive seals’ tolerance to such conditions, which could have translatable value for the current understanding and treatment of cardiovascular and respiratory pathologies in humans.

The Science Seminar Series is sponsored by the Thomas J. Long School of Pharmacy and Health Sciences Department of Physiology and Pharmacology, the College of the Pacific departments of Biological Sciences and Chemistry, the School of Engineering and Computer Science Bioengineering Department and the Office of the Provost.

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